Insidermedicine In Depth - May 5, 2011
The results of controlled-clinical trials cannot always predict how people with asthma will respond to therapy in a real-world setting, according to research published in the the New England Journal of Medicine. Signs that your asthma is not fully controlled with the medication you are taking include: • Having asthma symptoms during the day or night • Need to use your quick-relief or rescue inhaler more than twice a week • Peak flow rate is less than 80% of your normal Researchers from the University of Aberdeen conducted two studies in a real-world setting to determine whether drugs known as leukotriene-receptor antagonists are as helpful for controlling problem asthma symptoms as other more conventional drugs. In the first study, over 300 patients whose quality of life was impaired because of their asthma symptoms despite treatment received either a leukotriene-receptor antagonist or an inhaled steroid. In the second study, a similar group of over 350 patients received a leukotriene-receptor antagonist or a long-acting beta2-agonist as an add-on to inhaled steroid therapy. Both trials lasted for two years. By two months, statistical analyses determined that the leukotriene-receptor antagonist therapy was as effective as the two approaches at two months, but it remained unclear whether this therapy remained similarly effective through to the end of the two year studies. According to today's research, it remains unclear whether leukotriene-receptor antagonists are as ...Asthma — Comprehensive overview covers symptoms, treatment of this
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